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Human transmission sends bird flu fears flying
By Marwaan Macan-Markar

BANGKOK - In an effort to thwart a global panic, international health agencies and government officials are cautioning against fears that could arise from the first probable case of human-to-human transmission of bird flu in Thailand.

Since the death of a 26-year-old Thai woman last week, the World Health Organization (WHO) has jumped to action, and Thai health and agriculture officials have met to decide what to do next in their battle to eradicate the disease. Prime Minister Thaksin Shinawatra also called an emergency meeting on avian influenza on Wednesday.

Despite solid evidence that the case is one that could set off a human pandemic, the finding is significant because the deadly H5N1 virus could become a public health threat if it gains the capacity to pass from person to person.

The WHO's tone - in the wake of an announcement on Tuesday to explain the death of the Thai woman - was in marked contrast to the alarm it raised in January, when this year's first outbreak of bird flu was raging across Asia.

At that time, the Geneva-based United Nations health agency warned of a pandemic that could be worse than AIDS, killing millions, if the H5N1 strain of avian flu were to mutate and be passed from one person to another. No human being, the WHO pointed out, had immunity against this potential new virus.

On Tuesday, however, the WHO's representative in Thailand, Dr Kumara Rai, said, "There is no reason to panic.

"Based on evaluations so far, there is no significant public health threat," Rai told Inter Press Service. "There is no evidence of mutation or reassortment of the virus."

To be doubly sure, the WHO will send specimens of the bird-flu virus that probably led to the death of the Thai woman, Pranee Thonchan, to its collaborating center in the United States.

The WHO's call for calm came shortly after the Thai government announced here that it had detected the first probable case of a person infecting another with avian influenza.

According to Thai authorities, Pranee had been infected by the avian-flu virus while looking after her 11-year-old daughter, who had been hospitalized with the disease. Her daughter, Sakuntala, died on September 8 in the north-central province of Khampaeng Phet.

Pranee, who died of the disease on September 20, had been away in another part of the country when Sakuntala fell ill and had returned to care for her soon after.

Pranee could have contracted the virus "from the sick daughter, [whom] she was taking care of very closely at the hospital", the Thai government explained in a statement.

The deaths brought to 10 the number of Thais who have died because of the H5N1 virus during its two outbreaks this year. Of these, nine people died after coming into direct contact with infected poultry - the usual source of infection. But Pranee had contact only with an ill child, not any birds, according to the WHO.

Yet Dr Rai and Thai health authorities are drawing attention to other details surrounding the death of the mother and daughter to portray the first case of human-to-human transmission as more of a one-off event. No health workers in the hospital where the mother contracted the disease have been infected, they say, suggesting the possibility that the virus was weak.

"This shows that the efficiency of the transmission of the probable virus was low," said Rai. "If it was efficient, it would have been worse."

But that is no reason for complacency toward controlling the spread of the lethal virus, declared the Food and Agricultural Organization (FAO). Tuesday's announcement reinforced the need to control and eradicate the virus, He Changchui, FAO's regional representative for Asia and the Pacific, said at a press conference.

The FAO wants to see "further evidence and information to help us understand if and what may have changed in the biology and genetic make-up of the incriminated virus to give rise to this probable human-to-human transmission", said He.

On Monday, the Rome-based UN food agency described the bird-flu epidemic in Asia as a "crisis of global importance" and warned that the virus will "not probably be eradicated in the near future".

Since July, six Asian countries have reported outbreaks, including China, Vietnam, Cambodia, Malaysia and Thailand. Vietnam, the other Asian country as badly hit by the virus as Thailand, has had 20 deaths due to the disease.

The scale of the spread is less than what it was during the first major outbreak early this year, when eight Asian countries were hit, including two-thirds of Thailand's 76 provinces. In an effort to contain avian flu at that time, more than 100 million chickens were slaughtered or died due to the disease. Thailand, the world's fourth-largest chicken exporter, culled more than 40 million birds during that episode.

Avian influenza, which is transmitted through the air and is released in nasal secretion and the feces of infected birds, caused alarm in 1997 after an outbreak of the H5N1 strain of the virus killed six people in Hong Kong.

In August this year, China's state-run Xinhua News Agency reported that the H5N1 virus had been found in pigs, indicating the virus was no longer limited to the poultry family as had been the case hitherto. The account alarmed public health experts, since this reported first case meant that the avian-flu virus had mutated into a form that could lead to human-to-human infections.

(Inter Press Service)


Sep 30, 2004



Thailand wants a shot at bird flu vaccine
(Jul 22, '04)

Moment of truth nears on bird flu
(Mar 3, '04)

Lessons from the bird flu epidemic
(Feb 21, '04)

Bird flu fear grips Thailand
(Jan 27, '04)

 

         
         
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